Plexus Metaburn Review: Ingredients, Cost & Does It Work?

Plexus Metaburn is the newest fat burner from Plexus Worldwide — but is it the standout the marketing suggests? It’s sold individually through the website or an ambassador, or as part of a broader weight-loss kit claiming to cover everything needed for weight loss. We’re not entirely sure how Plexus landed on this particular ingredient combination, but we’re doubtful it’s quite as effective as advertised.

Our research team dug into the cost, the clinical research, and even social media pages to see what real users were saying about Plexus Metaburn’s effects, alongside the actual science behind each ingredient.

What Is Plexus Metaburn?

Plexus Metaburn is a multi-action blend marketed to boost fat-burning metabolism while supporting mood and brain health, with a particular focus on stubborn fat in the hips, thighs, and waist. The company describes it as a unique combination of exotic botanicals aimed at supporting weight-management goals — claims we’d note are the manufacturer’s own.

The company also claims Metaburn can noticeably reduce stubborn fat (leading to better-fitting clothes), support healthy energy levels, improve mood, and enhance mental focus. That naturally raises a question: if Plexus Slim already works as claimed, why is Metaburn necessary at all? Before answering that, it’s worth looking at what research says about a few shared ingredients: green tea has documented anti-bacterial, anti-viral, and anti-obesity effects, per Proceedings of the Japanese Academy; caffeine consumption may “promote weight, BMI and body fat reduction,” according to Critical Reviews in Food Science and Nutrition; and grains of paradise may induce thermogenesis in male subjects, per the British Journal of Nutrition.

Who Makes Metaburn?

Plexus Worldwide, based in Scottsdale, Arizona, also makes Plexus Slim, Plexus Slim Hunger Control, VitalBiome, and Plexus Lean — a fairly weight-loss-heavy lineup. The company also runs group accountability programs like the Plexus Slimdown Challenge and Plexus Fast Start.

Better Business Bureau

Plexus Worldwide LLC holds an “A+” BBB rating, accredited since December 2019, with 86 customer reviews averaging 3.52 out of 5 stars. Over the past three years, the company has recorded 50 complaints, with all 22 filed in the past 12 months successfully resolved.

Plexus Metaburn Ingredients

Given how many supplements and shakes Plexus already sells, some ingredient overlap was inevitable — but as a complete formula, Metaburn’s combination is unique to the brand. It includes N-Acetyl Tyrosine, Green Tea, Caffeine, L-Theanine, Rhodiola Root Extract, Grains of Paradise Extract, Forskohlii Root Extract, AstraGin, Chinese Ginseng, Guarana Seed Extract, and 5-HTP Seed Extract.

A Closer Look at the Ingredients

It’s a long list, and one built largely from ingredients that have circulated the supplement industry for years in various combinations and doses.

N-Acetyl Tyrosine

Once thought to help alleviate general stress, a 2007 study clarified its actual role is reducing cognitive decline tied specifically to physical stressors — “an effect of interest to almost no one outside the military,” as Dr. Simon Young put it in the Journal of Psychiatry and Neuroscience.

Green Tea

Green tea’s antioxidant effects offer protective benefits, per Food and Chemical Toxicology, and a study in Chinese Medicine found “long-term consumption of tea catechins could be beneficial against high-fat-diet-induced obesity” — the specific finding Plexus highlights in its marketing.

Caffeine

The world’s most widely used stimulant. Research in the American Journal of Clinical Nutrition confirms “caffeine/coffee stimulates the metabolic rate in both control and obese individuals.”

L-Theanine

Small, short-term studies have repeatedly shown L-theanine may help reduce anxiety, according to UC Berkeley’s Berkeley Wellness program.

Rhodiola Root Extract

Preliminary research suggests rhodiola may improve mood, with one study finding effects comparable to a prescription antidepressant, per the National Institutes of Health.

Grains of Paradise Extract

Research in the Journal of Nutritional Science and Vitaminology suggests it may improve energy expenditure and reduce fat in humans.

Forskohlii Root Extract

Human research remains thin — one 30-participant study showed a positive result, but with variance too wide to be considered strong scientific proof, though the journal Obesity did conclude “forskolin is a possible therapeutic agent for the management and treatment of obesity.”

AstraGin

A blend of Astragalus membranaceus and Panax notoginseng with no direct link to weight loss on the official Plexus site. According to its manufacturer, Nuliv Science, AstraGin “may help support normal human performance” mainly when paired with amino acids, creatine, or similar compounds — none of which are actually part of AstraGin itself.

Chinese Ginseng

Panax ginseng offers no established weight-loss benefit.

Guarana Seed Extract

A natural caffeine source, effectively another stimulant alongside green tea and caffeine already in the formula.

5-HTP Seed Extract

Barely studied for weight loss or general health, though a couple of small studies (fewer than 50 combined participants) suggest it may support better food choices with prolonged use.

What Are the Plexus Metaburn Claims?

Plexus makes a fair number of confident claims here, and our researchers were concerned that many are phrased as guarantees rather than possibilities — improved metabolism, a slight energy boost, better focus and mood, better-fitting clothes, and a smaller number on the scale — without the “results vary” disclaimers you’d typically expect on an unreviewed supplement.

Will Metaburn Work as Promised?

The proprietary blend totals 567mg, and since ingredients are typically listed in order of concentration, the first two or three — N-acetyl tyrosine, green tea, and caffeine — likely make up most of that weight. Two of those three, plus guarana further down the list, are stimulants, meaning much of the formula’s effect probably comes down to central nervous system stimulation rather than anything more novel.

Where Can You Buy the Fat Burner?

Plexus products should only be purchased through Plexus Worldwide directly or an authorized ambassador — third-party listings on Amazon or eBay aren’t sanctioned by the company.

How Much Does Plexus Metaburn Cost?

One bottle (60 capsules, a one-month supply at two daily) costs $49.00, dropping to $42.26 with a subscription after three months, tied to a mandatory monthly auto-ship commitment.

Pros and Cons of Plexus Metaburn

Pros: Caffeine can genuinely boost energy and focus, green tea delivers real antioxidants, and pricing runs a bit lower than some comparable products.

Cons: The proprietary blend hides individual ingredient amounts, it’s fundamentally a caffeine-based product like thousands of others, the best price requires a monthly subscription, and we found no clear details on how to cancel that subscription.

The Bottom Line on Plexus Metaburn

Metaburn’s release leaves us — and likely plenty of existing Plexus users — a little puzzled. If a company already sells a multi-product weight-loss kit claimed to cover everything needed, why introduce another supplement? Setting that question aside, the available research doesn’t suggest Metaburn’s specific ingredient combination is the most effective possible formula. As always, the most reliable path to weight-loss results comes from consistent diet and exercise habits, with any supplement playing, at best, a supporting role.

Explore more Fat Burner reviews and guides on our site.

For general guidance on healthy weight management, see the resources available from Mayo Clinic.