Plexus BioCleanse Review: 3 Real Facts About Weight Gain

Some Plexus BioCleanse users report gaining weight rather than losing it — a striking contradiction for a product marketed specifically around weight-loss support. This Plexus BioCleanse review checked what’s actually happening.

How We Researched This Plexus BioCleanse Review

This Plexus BioCleanse review checked the general research on internal cleanse supplements, the documented risks of dehydration and electrolyte imbalance from this product category, and the company’s actual BBB complaint trend.

Plexus BioCleanse Review: What Is It?

Made by Plexus Worldwide (Scottsdale, Arizona), Plexus BioCleanse is a vegetarian, gluten-free digestive cleanse supplement marketed to remove harmful microbes and toxins, promote regularity, and reduce gas and bloating, available in 60, 120, and 180 capsule sizes.

What the Research Actually Shows

• Journal of Dietary Supplements: internal cleanse supplements like this one can genuinely dehydrate the body, cause electrolyte imbalances, and produce diarrhea as a common side effect — real risks worth taking seriously.
• Journal of International Medical Research: magnesium hydroxide (a common cleanse ingredient) may work better than bulk laxatives for constipation in some elderly patients specifically.
• International Journal of Cosmetic Science: vitamin C is a genuine antioxidant supporting collagen production for skin, tendons, and blood vessels — a real secondary benefit unrelated to detox claims.

Does the Body Need a “Cleanse”?

Scientific research generally supports the body’s own innate detoxification ability without supplemental intervention — the liver and kidneys already handle this. Foods that support digestion and regularity offer a longer-lasting, more sustainable path than a “quick fix” cleanse supplement.

Why Some Users Report Weight Gain

This is a real, documented pattern worth understanding: rather than the promised weight loss, some Plexus BioCleanse users report gaining weight. This may relate to how the body responds to dehydration and electrolyte shifts from the laxative-adjacent mechanism — water retention rebound after a diuretic/laxative effect is a known phenomenon that can present as apparent weight gain.

Side Effects

Reported effects include nausea, dehydration, and diarrhea — consistent with the broader research on cleanse supplements generally. Adequate water intake is important if you use this product, given the genuine dehydration risk.

A Note on the BBB Trend

Plexus Worldwide holds an A+ BBB rating (accredited since December 2019) with a 3.62/5 customer review average from 86 reviews. Worth noting: of 51 total complaints over three years, 23 came in just the past 12 months — a real uptick worth monitoring, even against an otherwise solid overall rating.

Who Plexus BioCleanse Actually Makes Sense For

This fits people specifically seeking short-term digestive regularity support who are prepared to drink plenty of water and don’t expect meaningful weight loss. It’s a poor fit for anyone buying it specifically for weight loss — some users report the opposite effect — or anyone prone to dehydration-related side effects.

Frequently Asked Questions

The Bottom Line

Plexus BioCleanse’s “detox” premise isn’t strongly scientifically supported, and the documented pattern of users reporting weight gain instead of loss is a real concern worth taking seriously. This Plexus BioCleanse review found a digestive supplement whose actual results can run counter to its core marketing claim.

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